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Avvio del carcinoma metastatico della mammella dalla Targeting del duttale con Adenovirus-Cre: A Novel modello di topo transgenico di cancro al seno
JoVE 杂志
医学
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JoVE 杂志 医学
Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer
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Avvio del carcinoma metastatico della mammella dalla Targeting del duttale con Adenovirus-Cre: A Novel modello di topo transgenico di cancro al seno

22,830 Views

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07:13 min

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March 26, 2014

DOI:

10.3791/51171-v

DOI:
10.3791/51171-v

•

07:13 min
March 26, 2014

•

4 Views
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1Tumor Microenvironment and Metastasis Program,Wistar Institute, 2Department of Pathology and Lab Medicine, Perelman School of Medicine,University of Pennsylvania, 3Department of Microbiology and Immunology and Department of Genetics,Geisel School of Medicine at Dartmouth, 4Division of Endocrine and Oncologic Surgery, Department of Surgery, Perelman School of Medicine,University of Pennsylvania, 5Rena Rowan Breast Center, Abramson Cancer Center,University of Pennsylvania, 6Center for Advanced Medicine,University of Pennsylvania

Summary

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Attivazione di mutazioni latenti con adenovirus-Cre nei risultati mammarie sistema duttale in un carcinoma mammario metastatico clinicamente rilevante. Incorporazione di un promotore YFP consente di tenere traccia di cellule tumorali metastatiche distali. Questo modello è utile per studiare metastasi latente, immunità anti-tumorale, e per la progettazione di nuove immunoterapie per trattare il cancro al seno.

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Cite this Article

Rutkowski, M. R., Allegrezza, M. J., Svoronos, N., Tesone, A. J., Stephen, T. L., Perales-Puchalt, A., Nguyen, J., Zhang, P. J., Fiering, S. N., Tchou, J., Conejo-Garcia, J. R. Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer. J. Vis. Exp. (85), e51171, doi:10.3791/51171 (2014).

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