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Inchworming: A Novel Motor Stereotypy in the BTBR T+ Itpr3tf/J Mouse Model of Autism
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Inchworming: A Novel Motor Stereotypy in the BTBR T+ Itpr3tf/J Mouse Model of Autism

Inchworming: A Novel Motor Stereotypy in the BTBR T+ Itpr3tf/J Mouse Model of Autism

11,445 Views

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08:03 min

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July 05, 2014

DOI:

10.3791/50791-v

DOI:
10.3791/50791-v

•

08:03 min
July 05, 2014

•

2 Views
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1Departments of Paediatrics and Clinical Neurosciences, Alberta Children’s Hospital Research Institute,University of Calgary Faculty of Medicine, 2Department of Psychology, Neuroscience Program,Trinity College

Summary

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Inchworming is a highly repetitive synchronous digging motion displayed by BTBR T+ Itpr3tf/J (BTBR) mice when placed in a testing cage with sufficient sawdust bedding. The procedure is a modification of the juvenile social interaction protocol and is used here to assess repetitive motor stereotypies relevant to Autism Spectrum Disorder.

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InchwormingMotor StereotypyBTBR T+ Itpr3tf/J MouseAutism Spectrum DisorderRepetitive BehaviorJuvenile Social InteractionC56BL/6J Mouse

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Smith, J. D., Rho, J. M., Masino, S. A., Mychasiuk, R. Inchworming: A Novel Motor Stereotypy in the BTBR T+ Itpr3tf/J Mouse Model of Autism. J. Vis. Exp. (89), e50791, doi:10.3791/50791 (2014).

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