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Chapters
- 00:05Title
- 01:15Preparation for Surgery
- 05:13Left Side Subtotal Nephrectomy
- 06:12Representative Nephrectomy Results
- 08:23Conclusion
A two-stage method to establish chronic kidney disease (CKD) in the Lewis rat by surgically removing 5/6th of renal mass is described. Combination of the surgical procedure, NOS-inhibition and a high-salt diet leads to a model resembling human CKD, allowing study of causal mechanisms and development of novel therapeutic interventions.
