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A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
JoVE 杂志
医学
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JoVE 杂志 医学
A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
DOI:

13:42 min

July 17, 2012

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Chapters

  • 00:05Title
  • 01:23Induction of Anesthesia
  • 02:49Thoracotomy and Heart Preparation
  • 04:16Coronary Artery Instrumentation
  • 05:19Chest Closure and Myocardial Ischemia and Reperfusion
  • 06:56Infarct Size Assessment with Reperfusion Time up to 3 Days
  • 09:38Alternative Heart Preparation for Histology
  • 11:09Results: The Murine Chronic Closed-chest Model Allows a More Lifelike Approach to Myocardial Ischemia and Reperfusion
  • 13:19Conclusion

Summary

自动翻译

Surgical trauma induces an inflammatory response. Cytokines and endogenous ligands are known to modulate myocardial infarct size following ischemia and reperfusion. We present a modified closed-chest model of murine ischemia and reperfusion using hanging weights to minimize effects of thoracotomy.

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