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Use of Human Perivascular Stem Cells for Bone Regeneration
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May 25, 2012
DOI:
1Dental and Craniofacial Research Institute and Section of Orthodontics,School of Dentistry, UCLA, 2UCLA and Orthopaedic Hospital, Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center,UCLA, 3Department of Bioengineering,UCLA, 4Center for Cardiovascular Science,University of Edinburgh
Summary
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Human perivascular stem cells (PSCs) are a novel stem cell class for skeletal tissue regeneration similar to mesenchymal stem cells (MSCs). PSCs can be isolated by FACS (fluorescence activated cell sorting) from adipose tissue procured during standard liposuction procedures, then combined with an osteoinductive scaffold to achieve bone formation in vivo.
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Human Perivascular Stem CellsPSCsBone RegenerationFACS-sorted PopulationPericytesAdventitial CellsMesenchymal Stem CellsOsteogenic DifferentiationPro-osteogenic CytokinesAnimal ModelsMuscle Pouch ImplantationCalvarial DefectFemoral Segmental DefectEctopic Bone FormationPolyethylene BarK-wiresCritical Size DefectStem CellsGrowth FactorsXenograftingOrthotopic Bone Regeneration Models
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James, A. W., Zara, J. N., Corselli, M., Chiang, M., Yuan, W., Nguyen, V., Askarinam, A., Goyal, R., Siu, R. K., Scott, V., Lee, M., Ting, K., Péault, B., Soo, C. Use of Human Perivascular Stem Cells for Bone Regeneration. J. Vis. Exp. (63), e2952, doi:10.3791/2952 (2012).
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