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新型抗癌药物使用手术标本肿瘤植的发展方法

JoVE 杂志
医学

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JoVE 杂志医学

Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens

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新型抗癌药物使用手术标本肿瘤植的发展方法

16,347 Views

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09:26 min

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July 29, 2011

DOI:

DOI:

•

09:26 min

July 29, 2011

•

4 Views

Kaushal Joshi¹, Habibe Demir¹, Ryosuke Yamada¹, Takeshi Miyazaki¹, Abhik Ray-Chaudhury², Ichiro Nakano¹

¹Department of Neurological Surgery,The Ohio State University Medical Center, ²Department of Pathology,The Ohio State University Medical Center

Summary

在这里，我们的脑肿瘤的手术切除标本，被称为“肿瘤块法”建立了药物疗效检测的一种方法。使用这种方法，我们可以评估药物的疗效没有打破实体肿瘤的微环境。为了验证这种方法的可靠性，我们描述了具有代表性的数据，与我们当前的第一线化疗药物替莫唑胺治疗脑胶质瘤标本。

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