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Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens
 

Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens

Article DOI: 10.3791/2846-v • 09:26 min • July 29th, 2011
July 29th, 2011 •
1, 1, 1, 1, 2, 1
1Department of Neurological Surgery, The Ohio State University Medical Center, 2Department of Pathology, The Ohio State University Medical Center

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Here, we established a method for drug efficacy testing with surgical specimens of brain tumors, termed “tumor explant method”. With this method, we can evaluate drug efficacy without breaking the microenvironment of solid tumors. To validate reliability of this method, we describe representative data with our glioma specimen treated with the current first-line chemotherapeutic agent, temozolomide.

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Novel Anti-cancer Drug Development Tumor Explants Surgical Specimens Malignant Glioma Drug Efficacy Tests Pre-clinical Phase In Vitro Culture Cell Lines Phenotypic Alterations Genetic Alterations Epigenetic Alterations Xenograft Models Immunodeficient Mice Microenvironment Undissociated Tumor Blocks Treatment Effects Evaluation Temozolomide (TMZ) Intratumoral Injection Drug Candidates Analysis
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