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Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents
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September 15, 2011
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Partially isolated cortex (“undercut”) is an efficient animal model of posttraumatic epileptogenesis. Here we demonstrate how to make a novel surgical device and use it to make more precise and consistent lesions to generate this model.
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Undercut ModelPosttraumatic EpileptogenesisRodentsSurgical ProcedureSensorimotor CortexWhite MatterIsolated CortexCerebral CortexBrain SlicesEpileptiform DischargesElectrical SeizuresBehavior SeizuresAnimal ModelTraumatic Brain InjuryPrecise Cortical LesionsSmall Rodent BrainSurgery TechniqueSurgical DeviceCutting DepthCutting AngleConsistent ResultsStudy On Mechanisms
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Xiong, W., Ping, X., Gao, J., Jin, X. Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents. J. Vis. Exp. (55), e2840, doi:10.3791/2840 (2011).
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