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A Procedure for Studying the Footshock-Induced Reinstatement of Cocaine Seeking in Laboratory Rats
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January 06, 2011
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Animal models of relapse, known as reinstatement procedures, have been used extensively to study the role of stress in relapse to drug seeking. Here, we report on a method for inducing the reinstatement of cocaine seeking in laboratory rats via acute exposures to mild, intermittent electric footshock.
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Footshock-induced ReinstatementCocaine SeekingLaboratory RatsDrug AddictionRelapseAnimal ModelsNeurobiologyPhenomenologyReinstatement ProceduresDrug Self-administration ModelOperant ResponseExtinctionDrug SeekingTraining DrugDrug-associated CuesStressorAcute Non-contingent ExposureEnvironmental StimuliStressMild Intermittent Electric Footshocks
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Kupferschmidt, D. A., Brown, Z. J., Erb, S. A Procedure for Studying the Footshock-Induced Reinstatement of Cocaine Seeking in Laboratory Rats. J. Vis. Exp. (47), e2265, doi:10.3791/2265 (2011).
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