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Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System
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11:53 min
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October 26, 2010
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Parkinson's disease has been related to the exposure to pesticides. Here we show a method to deliver pesticides using a gastric tube at the desired concentration and a method to analyze their effect in alpha-synuclein accumulation in the enteric nervous system.
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Rotenone AdministrationGavage MethodImage AnalysisAlpha-synuclein InclusionsEnteric Nervous SystemParkinson’s Disease PathologyNeuropathological StagingOlfactory BulbDorsal Motor Nucleus Of The VagusIntermediolateral Nucleus Of The Spinal CordSubstantia NigraPesticide ExposureRotenone Effects On ENSMitochondrial Complex I InhibitionLipophylic PesticideGastrointestinal AbsorptionHepatoportal SystemPesticide Administration Method
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Pan-Montojo, F. J., Funk, R. H. Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System. J. Vis. Exp. (44), e2123, doi:10.3791/2123 (2010).
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