Classical fear conditioning paradigm was adapted for human participants in a fully immersive virtual reality setting. Using a discrimination paradigm, conditioned fear, cue and context memory retention, and extinction was measured with skin conductance response to dynamic virtual snakes and spiders (the conditioned stimuli) in two distinct virtual contexts.
Huff, N. C., Zielinski, D. J., Fecteau, M. E., Brady, R., LaBar, K. S. Human Fear Conditioning Conducted in Full Immersion 3-Dimensional Virtual Reality. J. Vis. Exp. (42), e1993, doi:10.3791/1993 (2010).