A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Kawtar Arizkane; Kevin Geistlich; Laurine Moindrot; Emma Risson; Sandrine Jeanpierre; L&#233;a Barral; Ana&#235;lle Bobard; Giulio Menegazzi; Thibault Voeltzel; V&#233;ronique Maguer-Satta; Sylvain Lefort

doi:10.3791/64736

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A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

JoVE Journal
Biology

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JoVE Journal Biology

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

2,389 Views

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09:07 min

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December 16, 2022

DOI:

10.3791/64736-v

DOI:

10.3791/64736-v

•

09:07 min

December 16, 2022

•

15 Views

Kawtar Arizkane^1,2,3, Kevin Geistlich^1,2,3,4, Laurine Moindrot^1,2,3, Emma Risson^1,2,3, Sandrine Jeanpierre^1,2,3,4, Léa Barral^1,2,3, Anaëlle Bobard^1,2,3, Giulio Menegazzi⁵, Thibault Voeltzel^1,2,3, Véronique Maguer-Satta^1,2,3, Sylvain Lefort^1,2,3

¹Centre de Recherche en Cancérologie de Lyon, ²Centre de Recherche en Cancérologie de Lyon, ³Université de Lyon, ⁴Centre Léon Bérard, ⁵Department of Experimental and Clinical Biomedical Sciences Mario Serio,Università degli Studi di Firenze

Summary

Here, we describe an easy-to-implement, standardized, microphysiological system that reflects the complexity of the human bone marrow's in vivo structure, providing a pertinent model to finely study a broad range of normal and pathological events.

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A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

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