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Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
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JoVE Journal Neuroscience
Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

English

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2,038 Views

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09:49 min

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January 20, 2023

DOI:

10.3791/64592-v

DOI:
10.3791/64592-v

•

09:49 min
January 20, 2023

•

9 Views
, , , , , , , ,
1Division of Medical Sciences,University of Victoria, 2Island Medical Program,University of British Columbia

Summary

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Here, it is demonstrated how an awake closed-head injury model can be used for examining the effects of repeated mild traumatic brain injury (r-mTBI) on synaptic plasticity in the hippocampus. The model replicates important features of r-mTBI in patients and is used in conjunction with in vitro electrophysiology.

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Synaptic PlasticityAwake Closed-head Injury ModelMild Traumatic Brain Injury (mTBI)Transverse Hippocampal SlicesNeurological Assessment Protocol (NAP)Electrophysiological RecordingsBrain DissectionSlice Preparation

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Christie, B. R., Gross, A., Willoughby, A., Grafe, E., Brand, J., Bosdachin, E., Reid, H. M. O., Acosta, C., Eyolfson, E. Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury. J. Vis. Exp. (191), e64592, doi:10.3791/64592 (2023).

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