Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

Simon Ollivier; Mathieu Fanuel; H&#233;l&#232;ne Rogniaux; David Ropartz

doi:10.3791/63451

Journal

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Chemistry

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Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

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Chemistry

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JoVE Journal Chemistry

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

3,798 Views

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08:40 min

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January 20, 2022

DOI:

10.3791/63451-v

DOI:

10.3791/63451-v

•

08:40 min

January 20, 2022

•

22 Views

Simon Ollivier^1,2, Mathieu Fanuel^1,2, Hélène Rogniaux^1,2, David Ropartz^1,2

¹INRAE, UR BIA, F-44316 Nantes, France, ²INRAE, BIBS Facility, F-44316 Nantes, France

Summary

Ion mobility spectrometry (IMS) is an interesting complement to mass spectrometry for the characterization of biomolecules, notably because it is sensitive to isomerism. This protocol describes a tandem IMS (IMS/IMS) experiment, which allows the isolation of a molecule and the generation of the mobility profiles of its fragments.

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Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

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