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Model af iskæmisk hjertesygdom og video-baseret sammenligning af Cardiomyocyte sammentrækning ved hjælp af hiPSC-afledte kardiomyocytter
JoVE Journal
Medicine
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JoVE Journal Medicine
Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes

Model af iskæmisk hjertesygdom og video-baseret sammenligning af Cardiomyocyte sammentrækning ved hjælp af hiPSC-afledte kardiomyocytter

English

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12,188 Views

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05:06 min

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May 05, 2020

DOI:

10.3791/61104-v

DOI:
10.3791/61104-v

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05:06 min
May 05, 2020

•

42 Views
, , , , , ,
1Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University, 2Institute of Laboratory Animals, Graduate School of Medicine,Kyoto University

Summary

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Vi præsenterer en model af iskæmisk hjertesygdom ved hjælp af kardiomyocytter stammer fra humane inducerede pluripotente stamceller, sammen med en metode til kvantitativ vurdering af vævsskader forårsaget af iskæmi. Denne model kan give en nyttig platform for narkotika screening og yderligere forskning i iskæmisk hjertesygdom.

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Cite this Article

Liu, Y., Liang, Y., Wang, M., Wang, C., Wei, H., Naruse, K., Takahashi, K. Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes. J. Vis. Exp. (159), e61104, doi:10.3791/61104 (2020).

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