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X-ray Diffraction of Intact Murine Skeletal Muscle as a Tool for Studying the Structural Basis of Muscle Disease
JoVE Journal
Developmental Biology
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JoVE Journal Developmental Biology
X-ray Diffraction of Intact Murine Skeletal Muscle as a Tool for Studying the Structural Basis of Muscle Disease

X-ray Diffraction of Intact Murine Skeletal Muscle as a Tool for Studying the Structural Basis of Muscle Disease

English

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6,805 Views

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08:26 min

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July 18, 2019

DOI:

10.3791/59559-v

DOI:
10.3791/59559-v

•

08:26 min
July 18, 2019

•

4 Views
,
1BioCAT, Dept. of Biological Sciences,Illinois Institute of Technology

Summary

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We present detailed protocols for performing small-angle X-ray diffraction experiments using intact mouse skeletal muscles. With the wide availability of transgenic mouse models for human diseases, this experimental platform can form a useful test bed for elucidating the structural basis of genetic muscle diseases

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Ma, W., Irving, T. C. X-ray Diffraction of Intact Murine Skeletal Muscle as a Tool for Studying the Structural Basis of Muscle Disease. J. Vis. Exp. (149), e59559, doi:10.3791/59559 (2019).

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