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A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System

A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System

English

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21,986 Views

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05:28 min

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August 15, 2019

DOI:

10.3791/59201-v

DOI:
10.3791/59201-v

•

05:28 min
August 15, 2019

•

43 Views
, , , ,
1Department of Bioengineering and Institute of Nanoscience and Technology,Hanyang University, 2Department of Internal Medicine, Section of Infectious Diseases,Yale University School of Medicine

Summary

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Here, we present a protocol using a mouse positioning device that enables the appropriate placement of mice for the intranasal administration of a brain-targeting peptide-siRNA formulation enabling effective gene silencing in the central nervous system.

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Cite this Article

Ullah, I., Chung, K., Beloor, J., Lee, S., Kumar, P. A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System. J. Vis. Exp. (150), e59201, doi:10.3791/59201 (2019).

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