Journal
/
/
两种技术来创建Hypoparathyroid小鼠:甲状旁腺切除术采用GFP腺和白喉毒素介导甲状旁腺消融
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal Medicine
Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

两种技术来创建Hypoparathyroid小鼠:甲状旁腺切除术采用GFP腺和白喉毒素介导甲状旁腺消融

14,120 Views

07:13 min

March 14, 2017

DOI:

07:13 min
March 14, 2017

6 Views
, , , ,

Summary

Automatically generated

Mice with acquired hypoparathyroidism would be useful for studying novel drug therapies for hypoparathyroidism. Two procedures to create such mice are demonstrated. The GFP-PTX mouse is generated by surgical parathyroidectomy guided by green fluorescing parathyroid glands. A second, non-surgical approach is based on parathyroid-specific expression of the diphtheria toxin receptor.

Read Article