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一个两亲性共聚物的阴离子聚合通过π-π堆积作用稳定嵌段共聚物胶束的制备
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Chemistry
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JoVE Journal Chemistry
Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
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一个两亲性共聚物的阴离子聚合通过π-π堆积作用稳定嵌段共聚物胶束的制备

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13,761 Views

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10:53 min

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October 10, 2016

DOI:

10.3791/54422-v

DOI:
10.3791/54422-v

•

10:53 min
October 10, 2016

•

10 Views
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1Leslie Dan Faculty of Pharmacy,University of Toronto

Summary

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生活在甲氧基聚乙二醇（MPEG-b -PPheGE）苯基缩水甘油醚（PheGE）的阴离子聚合的关键步骤进行说明。将所得嵌段共聚物胶束（带宽模型）的下生理学上得到有关条件装载阿霉素14％（重量％）和药物的持续释放超过4天。

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Cite this Article

Le Dévédec, F., Houdaihed, L., Allen, C. Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions. J. Vis. Exp. (116), e54422, doi:10.3791/54422 (2016).

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