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病原生物膜利用工程定额淬Lactonases防有毒中断
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Immunology and Infection
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JoVE Journal Immunology and Infection
Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
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病原生物膜利用工程定额淬Lactonases防有毒中断

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10,447 Views

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07:47 min

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January 01, 2016

DOI:

10.3791/53243-v

DOI:
10.3791/53243-v

•

07:47 min
January 01, 2016

•

3 Views
, , ,
1Department of Biochemistry,Yong Loo Lin School of Medicine, 2Department of Chemistry,University of Utah, 3Synthetic Biology Research Consortium,National University of Singapore

Summary

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Quorum-quenching enzymes are anti-virulent and anti-bacterial options that can mitigate pathogenesis without risk of incurring resistance, by preventing the expression of virulence factors and genes associated with antibiotic resistance and biofilm formation. In this study, we report a method that demonstrates the efficacy of quorum-quenching enzymes in bacterial biofilm disruption.

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Tay, S. B., Chow, J. Y., Go, M. K., Yew, W. S. Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases. J. Vis. Exp. (107), e53243, doi:10.3791/53243 (2016).

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