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Kimyasal Güvenlik Tarama ve Sistem Biyolojisi Veri Üretimi Gelişim Toksisite Tahliller Tabanlı İnsan Pluripotent Kök Hücre
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Kimyasal Güvenlik Tarama ve Sistem Biyolojisi Veri Üretimi Gelişim Toksisite Tahliller Tabanlı İnsan Pluripotent Kök Hücre
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June 17, 2015
DOI:
1Center of Physiology and Pathophysiology, Institute of Neurophysiology,University of Cologne, 2Department of Biology,University of Konstanz, 3Department of Statistics,Technical University of Dortmund, 4Leibniz Research Centre for Working Environment and Human Factors,Technical University of Dortmund
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Human Pluripotent Stem CellsDevelopmental Toxicity AssaysChemical Safety ScreeningSystems BiologyEmbryonic Stem CellsEmbryoid BodiesNeuroectodermal Progenitor CellsTranscriptome MicroarrayIn Vitro Toxicity TestingEarly Embryonic ToxicityTeratogenicityDevelopmental NeurotoxicityEpigenetic ChangesToxicity BiomarkersSystems Biology AnalysisAnimal Studies ReductionDrug DevelopmentChemical Safety Evaluation
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Shinde, V., Klima, S., Sureshkumar, P. S., Meganathan, K., Jagtap, S., Rempel, E., Rahnenführer, J., Hengstler, J. G., Waldmann, T., Hescheler, J., Leist, M., Sachinidis, A. Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation. J. Vis. Exp. (100), e52333, doi:10.3791/52333 (2015).
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