We have developed a mouse lung injury model by intra-tracheal injection of bacteria Pseudomonas aeruginosa. This model mimics lung injury during pneumonia and is clinically relevant.
Suresh Kumar, V., Sadikot, R. T., Purcell, J. E., Malik, A. B., Liu, Y. Pseudomonas aeruginosa Induced Lung Injury Model. J. Vis. Exp. (92), e52044, doi:10.3791/52044 (2014).