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通过鼻腔活检获得联合激光捕获显微切割的嗅觉神经元:一种可能的方法来研究治疗反应的精神障碍
JoVE Journal
Neuroscience
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JoVE Journal
Neuroscience
Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
Please note that all translations are automatically generated.
Click here for the English version.
通过鼻腔活检获得联合激光捕获显微切割的嗅觉神经元:一种可能的方法来研究治疗反应的精神障碍
DOI:
10.3791/51853-v
•
08:33 min
•
December 04, 2014
•
Soumya Narayan
,
Charlee McLean
,
Akira Sawa
,
Sandra Y. Lin
,
Narayan Rai
,
MariaMananita S. Hipolito
,
Nicola Cascella
,
John J.I. Nurnberger, Jr.
,
Koko Ishizuka
,
Evaristus A. Nwulia
1
Department of Psychiatry
,
Johns Hopkins University
,
2
Department of Psychiatry and Behavioral Sciences
,
Howard University
,
3
Department of Otolaryngology-Head and Neck Surgery
,
Johns Hopkins University
,
4
Department of Psychiatry
,
Sheppard Pratt Hospital
,
5
Department of Psychiatry
,
Indiana University
Chapters
00:05
Title
01:49
Laser-Capture Microdissection
03:48
Isolation of Total RNA and cDNA Synthesis
05:50
Real Time PCR Quantification
07:14
Reults: GSK-3β Expression in OE Neurons
07:53
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
在这项研究中,一种新的平台来调查在躁郁症(BD)的治疗的反应的突触体分子签名被开发和验证。从BD患者嗅上皮是通过鼻腔活检获得。那么激光捕获显微切割是结合实时RT PCR,调查BD锂反应的分子签名。
Tags
Olfactory Neurons
Nasal Biopsy
Laser-capture Microdissection
Bipolar Disorder
Lithium Carbonate
Wnt Signaling
Neuropsychiatric Disorders
Olfactory Epithelium
Treatment Response
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