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Immunology and Infection

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人源化的小鼠模型来研究细菌感染瞄准微血管

JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection

Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature

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人源化的小鼠模型来研究细菌感染瞄准微血管

14,454 Views

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11:40 min

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April 01, 2014

DOI:

10.3791/51134-v

DOI:

10.3791/51134-v

•

11:40 min

April 01, 2014

•

8 Views

Keira Melican^1,2, Flore Aubey^1,2, Guillaume Duménil^1,2

¹INSERM U970,Paris Cardiovascular Research Centre, ²Faculté de Médecine Paris Descartes,Université Paris Descartes

Summary

脑膜炎奈瑟氏菌是感染血管人类特定的病原体。在这个协议中人类微血管被移植人体皮肤上免疫功能低下小鼠引入鼠标。菌粘附到广泛的人类血管，导致紫癜皮疹通常在人类病例观察到的血管损伤和发育。

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