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Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

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8,228 Views

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07:38 min

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January 08, 2014

DOI:

10.3791/50958-v

DOI:
10.3791/50958-v

•

07:38 min
January 08, 2014

•

3 Views
, , ,
1Center for Bio/Molecular Science & Engineering,US Naval Research Laboratory, 2Joint Department of Biomedical Engineering,North Carolina State University and University of North Carolina at Chapel Hill

Summary

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Two adjacent fluids passing through a grooved microfluidic channel can be directed to form a sheath around a prepolymer core; thereby determining both shape and cross-section. Photoinitiated polymerization, such as thiol click chemistry, is well suited for rapidly solidifying the core fluid into a microfiber with predetermined size and shape.

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Microfluidic FabricationPolymeric FibersBiohybrid FibersPredesigned Size And ShapeSheath And Core FluidsViscosity And Hydrophilicity ControlFlow Rate ControlFiber Cross-sectionsPhotoinitiated Click ChemistriesPolymerizationEncapsulation Of Cells And Biological Components

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Boyd, D. A., Adams, A. A., Daniele, M. A., Ligler, F. S. Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape. J. Vis. Exp. (83), e50958, doi:10.3791/50958 (2014).

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