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January 04, 2012
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系统性基因传递和转染治疗胰腺癌的B型明胶为基础的设计nanovectors系统（氏族）的开发。他们可以通过与表皮生长因子受体（EGFR）的特异性多肽nanparticles表面改性，表皮生长因子受体受体目标和下降低细胞内谷胱甘肽的浓度高，如环境，释放质粒。
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Therapeutic Gene DeliveryTransfectionPancreatic Cancer CellsEpidermal Growth Factor Receptor-targeted Gelatin NanoparticlesPancreatic CancerGene TherapyDelivery SystemSustained Transgene ExpressionGelatinDNA EncapsulationPlasmid Supercoiled StructureTransfection EfficiencyThiolation Of GelatinSulfhydryl GroupsDisulfide BondGlutathionePoly(ethylene Glycol)PEG-modified GENSSystemic CirculationTumor MassNeovasculature
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Xu, J., Amiji, M. Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles. J. Vis. Exp. (59), e3612, doi:10.3791/3612 (2012).
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