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HLA - Igは効率のためのベースの人工抗原提示細胞生体外で拡大
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
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HLA - Igは効率のためのベースの人工抗原提示細胞生体外で拡大

日本語

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15,103 Views

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07:18 min

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April 11, 2011

DOI:

10.3791/2801-v

DOI:
10.3791/2801-v

•

07:18 min
April 11, 2011

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3 Views
, ,
1Immunology Graduate Program,Johns Hopkins University, 2Department of Internal Medicine,Far-Eastern Memorial Hospital, 3Department of Pathology,Johns Hopkins University, 4Institute of Cell Engineering,Johns Hopkins University

Summary

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抗原特異的T細胞の誘導と拡大のための新しいDCの独立した方法が記載されている。 HLA A2 - Igはベースの人工的な抗原提示細胞（aAPC）が効率的に多様な抗原特異性のCTLを拡大するHLA - A2制限されたペプチドがロードされます。この技術は、CTLベースの養子免疫療法のための大きな可能性を秘めている。

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Cite this Article

Chiu, Y., Schneck, J. P., Oelke, M. HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL. J. Vis. Exp. (50), e2801, doi:10.3791/2801 (2011).

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