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공동 stimulatory 신호 봉쇄와 Alloantigen 자극에 의​​해 사람 말초혈 Mononuclear 세포 Alloantigen 특정 Anergy의 유도
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Please note that all translations are automatically generated. Click here for the English version.

공동 stimulatory 신호 봉쇄와 Alloantigen 자극에 의​​해 사람 말초혈 Mononuclear 세포 Alloantigen 특정 Anergy의 유도

English

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14,287 Views

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11:55 min

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March 14, 2011

DOI:

10.3791/2673-v

DOI:
10.3791/2673-v

•

11:55 min
March 14, 2011

•

1 Views
, , , ,
1Medical Oncology,Dana Farber Cancer Institute, 2Department of Medicine,Brigham and Womens Hospital, 3Pediatric Oncology,Dana Farber Cancer Institute, 4Division of Hematology/Oncology,Children’s Hospital Boston

Summary

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본 논문은 인간의 말초 혈액 mononuclear 세포의 alloantigen 특정 anergy를 유도하는 간단한 기술을 설명합니다. 기술은 아닌 alloreactive 기증자의 세포를 생성하는 임상 적용할 수 있습니다. 이러한 세포의 주입은 면역 reconstitution를 개선하고 all​​ogeneic 조혈 줄기 세포 이식 후 독성을 줄일 수 있습니다.

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Davies, J. K., Barbon, C. M., Voskertchian, A. R., Nadler, L. M., Guinan, E. C. Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade. J. Vis. Exp. (49), e2673, doi:10.3791/2673 (2011).

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