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Tratamento medicamentoso por Cateter Venoso Central em um Modelo de Camundongo de Angiotensin II Aneurisma Abdominal Induzido anótico e monitoramento por ultrassom 3D
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Drug Treatment by Central Venous Catheter in a Mouse Model of Angiotensin II Induced Abdominal Aortic Aneurysm and Monitoring by 3D Ultrasound

Tratamento medicamentoso por Cateter Venoso Central em um Modelo de Camundongo de Angiotensin II Aneurisma Abdominal Induzido anótico e monitoramento por ultrassom 3D

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10:09 min

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August 04, 2022

DOI:

10.3791/64124-v

DOI:
10.3791/64124-v

•

10:09 min
August 04, 2022

•

5 Views
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1Division of Vascular Surgery, Department of General Surgery,Medical University of Vienna and Vienna General Hospital, 2Leeds Institute for Cardiovascular and Metabolic Medicine, School of Medicine,University of Leeds, 3Leeds Vascular Institute,Leeds General Infirmary, 4Department for Visceral, Thoracic and Vascular Surgery,Technical University of Dresden and University Hospital Carl-Gustav Carus, 5Division of Cardiovascular and Interventional Radiology, Division of Molecular and Gender Imaging, Department of Biomedical Imaging and Image Guided Therapy,Medical University of Vienna and Vienna General Hospital

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Este protocolo descreve a implantação consecutiva de uma bomba osmótica para induzir aneurisma aórtico abdominal por angiotensina II liberação em camundongos deficientes apolipoprotein E (ApoE) e de uma porta de acesso vascular com cateter venoso jugular para tratamento medicamentoso repetido. O monitoramento do desenvolvimento de aneurisma por ultrassom 3D é efetivamente realizado apesar dos implantes dorsais.

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Mouse ModelAbdominal Aortic AneurysmDrug TreatmentCentral Venous Catheter3D UltrasoundJugular Vein CatheterizationAPOE DeficientAnesthesiaSurgical ProcedureVascular Access SystemCatheter PreparationDisinfectionBlunt DissectionExternal Jugular Vein

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Ibrahim, N., Klopf, J., Bleichert, S., Bailey, M. A., Busch, A., Stiglbauer-Tscholakoff, A., Eilenberg, W., Neumayer, C., Brostjan, C. Drug Treatment by Central Venous Catheter in a Mouse Model of Angiotensin II Induced Abdominal Aortic Aneurysm and Monitoring by 3D Ultrasound. J. Vis. Exp. (186), e64124, doi:10.3791/64124 (2022).

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