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血管紧张素II诱导的腹主动脉瘤小鼠模型中中心静脉导管的药物治疗及3D超声监测
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August 04, 2022
DOI:
1Division of Vascular Surgery, Department of General Surgery,Medical University of Vienna and Vienna General Hospital, 2Leeds Institute for Cardiovascular and Metabolic Medicine, School of Medicine,University of Leeds, 3Leeds Vascular Institute,Leeds General Infirmary, 4Department for Visceral, Thoracic and Vascular Surgery,Technical University of Dresden and University Hospital Carl-Gustav Carus, 5Division of Cardiovascular and Interventional Radiology, Division of Molecular and Gender Imaging, Department of Biomedical Imaging and Image Guided Therapy,Medical University of Vienna and Vienna General Hospital
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该协议描述了在载脂蛋白E（ApoE）缺陷小鼠中通过血管紧张素II释放连续植入渗透泵以诱导腹主动脉瘤，以及使用颈静脉导管的血管通路端口进行重复药物治疗。尽管进行了背侧植入物，但通过 3D 超声可有效监测动脉瘤的发展。
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Ibrahim, N., Klopf, J., Bleichert, S., Bailey, M. A., Busch, A., Stiglbauer-Tscholakoff, A., Eilenberg, W., Neumayer, C., Brostjan, C. Drug Treatment by Central Venous Catheter in a Mouse Model of Angiotensin II Induced Abdominal Aortic Aneurysm and Monitoring by 3D Ultrasound. J. Vis. Exp. (186), e64124, doi:10.3791/64124 (2022).
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