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Generación de organoides cerebrales humanos para el modelado de enfermedades mitocondriales
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June 21, 2021
DOI:
1Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty,Heinrich Heine University, 2Institute of Neurobiology,Heinrich Heine University, 3Berlin Institute for Medical Systems Biology (BIMSB),Max Delbrueck Center for Molecular Medicine (MDC), 4Seaver Autism Center for Research and Treatment,Icahn School of Medicine at Mount Sinai, 5Max Delbrueck Center for Molecular Medicine (MDC)
Özet
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Describimos un protocolo detallado para la generación de organoides cerebrales derivados de células madre pluripotentes inducidas por humanos y su uso en el modelado de enfermedades mitocondriales.
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Le, S., Petersilie, L., Inak, G., Menacho-Pando, C., Kafitz, K. W., Rybak-Wolf, A., Rajewsky, N., Rose, C. R., Prigione, A. Generation of Human Brain Organoids for Mitochondrial Disease Modeling. J. Vis. Exp. (172), e62756, doi:10.3791/62756 (2021).
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