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非人灵长类动物模型中视网膜色素上皮移植治疗退行性视网膜疾病
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June 14, 2021
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1Department of Ophthalmology, Yong Loo Lin School of Medicine,National University of Singapore, 2Department of Ophthalmology,National University Hospital, Singapore, 3Institute of Molecular and Cell Biology (IMCB),Agency for Science, Technology and Research (A*STAR), 4Singapore Eye Research Institute (SERI), 5UCL Institute of Ophthalmology, 6Academic Clinical Program in Ophthalmology,Duke-NUS Medical School, 7Macula Center Saar, Eye Clinic Sulzbach,Knappschaft Hospital Saar, 8Department of Ophthalmology,University of Bonn
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由于解剖学和遗传相似性，非人灵长类动物（NHP）是研究人类视网膜细胞疗法的理想模型。本手稿描述了在NHP眼中进行视网膜色素上皮细胞的黄斑下移植方法以及预防与黄斑操作相关的术中并发症的策略。
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Seah, I., Liu, Z., Soo Lin Wong, D., Wong, W., Holder, G. E., Amutha Barathi, V., Lingam, G., Su, X., Stanzel, B. V. Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases. J. Vis. Exp. (172), e62638, doi:10.3791/62638 (2021).
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