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A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery
JoVE Journal
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A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

DOI:
10.3791/60292-v

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08:05 min

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November 08, 2019

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, , , , , , , ,
1Department of Microsurgery,Jesús Usón Minimally Invasive Surgery Centre, 2Stem Cell Therapy Unit,Jesús Usón Minimally Invasive Surgery Centre, 3Animal Modelling Unit,Jesús Usón Minimally Invasive Surgery Centre

Bölümler

  • 00:04Başlık
  • 01:26Free Skin Flap Model Surgery
  • 03:00Intraoperative Assessment
  • 05:18Postoperative Assessment and Tissue Sampling
  • 06:00Results: Ischemia-Reperfusion Injury in Reconstructive Microsurgery
  • 07:03Conclusion

Özet

Otomatik Çeviri

Otomatik Çeviri

Here, we describe a pre-clinical animal model for studying the pathophysiology of ischemia-reperfusion injury in reconstructive microsurgery. This free skin flap model based on the superficial caudal epigastric vessels in the rat may also allow for the evaluation of different therapies and compounds to counteract ischemia-reperfusion injury-related damage.

Etiketler

Pre-clinical Rat ModelIschemia-reperfusion InjuryReconstructive MicrosurgeryFlap FailureSuperficial Caudal Epigastric VesselsIschemiaReperfusionMicrosurgical ReconstructionInnate ImmunityVascular PedicleMicrocirculatory PerfusionMicrovascular AnastomosisTransit-time Ultrasound Flowmetry

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