Dergi
/
Tıp
/
A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies
JoVE Journal
Tıp
This content is Free Access.
JoVE Journal Tıp
A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies

A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies

DOI:
10.3791/59631-v

•

08:04 min

•

January 24, 2020

•

, ,
1Department of Ophthalmology,Stony Brook University, 2Department of Preventive Medicine,Stony Brook University, 3Medicon Pharmaceuticals, Inc.

Bölümler

  • 00:04Başlık
  • 01:25Nictitating Membrane Injection and Removal
  • 02:41Dry Eye Induction
  • 06:15Results: Representative Effects of Aqueous-Deficient Dry Eye Disease (DED) Induction
  • 07:19Conclusion

Özet

Otomatik Çeviri

Otomatik Çeviri

This article describes the development of a method to induce acute or chronic dry eye disease in rabbits by injecting concanavalin A to all portions of the orbital lacrimal gland system. This method, superior to those already reported, generates a reproducible, stable model of dry eye suitable for the study of pharmacological agents.

Etiketler

Rabbit ModelAqueous-deficient Dry Eye DiseaseConcanavalin ALacrimal Gland InjectionUltrasound GuidanceAnimal ModelDrug Efficacy StudiesPathophysiology

Article

Embed

ÇALMA LİSTESİNE EKLE

Usage Statistics

İlgili Videolar

Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19

A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury

Author Spotlight: Investigating the Mechanism of Action of Acupotomy in Treating Knee Osteoarthritis

Read Article