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脑震荡结合力与旋转与Vivo脑微透析的新型和转化大鼠模型
JoVE Journal
Nörobilim
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JoVE Journal Nörobilim
A Novel and Translational Rat Model of Concussion Combining Force and Rotation with In Vivo Cerebral Microdialysis
Please note that all translations are automatically generated. Click here for the English version.

脑震荡结合力与旋转与Vivo脑微透析的新型和转化大鼠模型

8,449 Views

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08:45 min

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July 12, 2019

DOI:

10.3791/59585-v

DOI:
10.3791/59585-v

•

08:45 min
July 12, 2019

•

12 Views
, , , , ,
1Research Center,Hôpital du Sacré-Cœur de Montréal, 2Research Center,Douglas Institute

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神经递质改变是一种神经功能障碍的机制,发生在脑震荡后,并造成有时灾难性的长期后果。这种大鼠模型结合了微透析,允许体内神经递质定量,与重量下降技术,以快速加速和减速的头部和躯干,人类颅骨创伤的一个重要因素。

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Massé, I. O., Moquin, L., Provost, C., Guay, S., Gratton, A., De Beaumont, L. A Novel and Translational Rat Model of Concussion Combining Force and Rotation with In Vivo Cerebral Microdialysis. J. Vis. Exp. (149), e59585, doi:10.3791/59585 (2019).

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