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誘導多能性幹細胞由来肝細胞を用いた家族性高コレステロール血症ひと肝臓キメラマウス モデル
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September 15, 2018
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1Tıp Fakültesi,University of Hong Kong-Shenzhen Hospital, 2The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine,University of Hong Kong, 3School of Biomedical Sciences, Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences,Chinese University of Hong Kong, 4Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences, Joint School of Life Sciences,Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, 5Laboratory of RNA, Chromatin, and Human Disease, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences, 6Research Centre of Heart, Brain, Hormone, and Healthy Ageing, Li Ka Shing Faculty of Medicine,University of Hong Kong, 7Hong Kong-Guangdong Stem Cell and Regenerative Medicine Research Centre,University of Hong Kong and Guangzhou Institutes of Biomedicine and Health
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ここでは、ひと誘導多能性幹細胞由来肝細胞を用いた家族性高コレステロール血症のひと肝臓キメラマウス モデルを生成するためのプロトコルを提案する.高コレステロール血症の新しい治療法をテストするための貴重なモデルです。
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Yang, J., Wong, L., Tian, X., Wei, R., Lai, W., Au, K., Luo, Z., Ward, C., Ho, W., Ibañez, D. P., Liu, H., Bao, X., Qin, B., Huang, Y., Esteban, M. A., Tse, H. A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes. J. Vis. Exp. (139), e57556, doi:10.3791/57556 (2018).
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