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使用人类流感病毒感染的斑马鱼模型到屏幕抗病毒药物和表征宿主免疫细胞反应
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January 20, 2017
DOI:
1Department of Molecular and Biomedical Sciences,University of Maine, 2Graduate School of Biomedical Sciences and Engineering,University of Maine, 3School of Biology and Ecology,University of Maine, 4Division of Intramural Research, Immunity, Inflammation and Disease Laboratory,National Institute of Environmental Health Sciences, NIH, 5Department of Chemical and Biological Engineering,University of Maine
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Systemic and localized zebrafish infection models for human influenza A virus are demonstrated. Using a systemic infection model, zebrafish can be used to screen antiviral drugs. Using a localized infection model, zebrafish can be used to characterize host immune cell responses.
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Sullivan, C., Jurcyzszak, D., Goody, M. F., Gabor, K. A., Longfellow, J. R., Millard, P. J., Kim, C. H. Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses. J. Vis. Exp. (119), e55235, doi:10.3791/55235 (2017).
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