Bu içeriği görüntülemek için JoVE aboneliği gereklidir. Oturum açın veya ücretsiz deneme sürümünü başlatın.
Döner disülfür Çapraz bağlı misellerin Üretimi için basit ve etkin Yaklaşım
Bölümler
- 00:05Başlık
- 00:46Synthesis of TD PEG5K-Cys4-Ebes8-CA8
- 03:57Preparation of PTX-loaded Micelles
- 05:44Hemolysis Assay
- 07:01Results: Characterizations of Reversible Disulfide Cross-linked Micelles
- 08:51Conclusion
To deliver cancer drugs to tumor sites with high specificity and reduced side effects, new methods based on nanoparticles are required. Here, we describe disulfide cross-linked micelles that can be easily prepared by hydrogen peroxide-mediated oxidation and are able to dissociate efficiently under a reducing tumor environment to release payloads.
