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Développement d'un fibrotique du foie Modèle induite de l'éthanol en Zebrafish pour étudier de cellules souches médiée hépatocytes Régénération
JoVE Journal
Gelişim Biyolojisi
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JoVE Journal Gelişim Biyolojisi
Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

Développement d'un fibrotique du foie Modèle induite de l'éthanol en Zebrafish pour étudier de cellules souches médiée hépatocytes Régénération

DOI:

10:42 min

May 13, 2016

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Bölümler

  • 00:05Başlık
  • 00:56Ethanol and Metronidazole Treatment and Liver Regeneration in Larval Zebrafish
  • 02:42Chemical Screens in EtOH/MTZ-treated Larval Zebrafish
  • 04:10Ethanol and Metronidazole Treatment, and Liver Regeneration in Adult Zebrafish
  • 05:24Adult Zebrafish Liver Fixation, Immunostaining, and Confocal Imaging
  • 07:30Results: Hepatocyte Regeneration in Ethanol-treated Zebrafish Liver
  • 09:25Conclusion

Özet

Otomatik Çeviri

Sustained fibrosis with deposition of excessive extracellular matrix proteins leads to cirrhosis. Alcohol abuse is one of the main causes of severe liver disease. We established an ethanol-induced zebrafish fibrotic liver model to study the mechanisms and strategies of promoting hepatocyte regeneration upon alcohol-induced injury.

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