Intravenous administration of endotoxin reliably elicits dose-dependent physiological and immunological alterations consistent with several pathological states. This reductionist approach permits the investigation, modeling and experimental modification of systemic inflammation and its downstream effects in man.
Fullerton, J. N., Segre, E., De Maeyer, R. P., Maini, A. A., Gilroy, D. W. Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation. J. Vis. Exp. (111), e53913, doi:10.3791/53913 (2016).