Isolatie van virale replicatie compartiment verrijkt Sub-nucleaire fracties uit adenovirus-geïnfecteerde normale menselijke cellen

We provide a novel strategy to isolate viral replication compartments (RC) from adenovirus (Ad)-infected human cells. This approach represents a cell-free system that can help to elucidate the molecular mechanisms regulating viral genome replication and expression as well as regulation of viral-host interactions established at the RC.