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极化神经组织工程三维蚕丝胶原蛋白为基础的模式
JoVE Journal
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JoVE Journal Biyomühendislik
Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue
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极化神经组织工程三维蚕丝胶原蛋白为基础的模式

12,220 Views

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06:17 min

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October 23, 2015

DOI:

10.3791/52970-v

DOI:
10.3791/52970-v

•

06:17 min
October 23, 2015

•

6 Views
, , , , ,
1Department of Biomedical Engineering,Tufts University, 2Pediatri Anabilim Dalı,University of Connecticut Health Center & Connecticut Children’s Medical Center

Özet

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Insight into the complex actions of the brain requires advanced research tools. Here we demonstrate a novel silk-collagen-based 3D engineered model of neural tissue resembling brain-like architecture. The model can be used to study neuronal network assembly, axonal guidance, cell-cell interactions and electrical activity.

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Silk-collagenPolarized NeuronsBrain-derived NeuronsNeural NetworkAxonal GuidanceCell-cell InteractionCell-matrix InteractionElectrical Function

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Cite this Article

Chwalek, K., Sood, D., Cantley, W. L., White, J. D., Tang-Schomer, M., Kaplan, D. L. Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue. J. Vis. Exp. (104), e52970, doi:10.3791/52970 (2015).

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