High-Quality Seizure-Like Activity from Acute Brain Slices Using a Complementary Metal-Oxide-Semiconductor High-Density Microelectrode Array System

Melissa L. Blotter; Isaac W. Stubbs; Jacob H. Norby; Maxwell Holmes; Ben Kearsley; Alexis Given; Kutter Hine; Micah R. Shepherd; R. Ryley Parrish

doi:10.3791/67065

Consistent Induction and Recording of Seizure-Like Activity Using CMOS-HD-MEAs

September 27, 2024

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

01:03 min

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Equipment Preparation for CMOS-HD-MEA Experimentation

01:27 min

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7 Views

Chip Preparation and Placement of Brain Slice to Record High-Quality Seizure-like Activity Using CMOS-HD-MEA System

04:06 min

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Melissa L. Blotter*^1,2, Isaac W. Stubbs*^1,2, Jacob H. Norby*^1,2, Maxwell Holmes^1,2, Ben Kearsley³, Alexis Given¹, Kutter Hine^1,4, Micah R. Shepherd⁵, R. Ryley Parrish^1,2

¹Department of Cell Biology and Physiology,Brigham Young University, ²Neuroscience Center,Brigham Young University, ³Department of Statistics,Brigham Young University, ⁴Biyoloji Bölümü,Brigham Young University, ⁵Fizik ve Astronomi bölümü,Brigham Young University

Özet

Here, we outline a protocol for using complementary metal-oxide-semiconductor high-density microelectrode array systems (CMOS-HD-MEAs) to record seizure-like activity from ex vivo brain slices.

Consistent Induction and Recording of Seizure-Like Activity Using CMOS-HD-MEAs

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Equipment Preparation for CMOS-HD-MEA Experimentation

Chip Preparation and Placement of Brain Slice to Record High-Quality Seizure-like Activity Using CMOS-HD-MEA System

Özet

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