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Enhanced Intestine-on-Chip Platform for Immunological Insight

Enhanced Intestine-on-Chip Platform for Immunological Insight

May 24, 2024

用于分析肠道粘膜免疫反应的免疫活性肠芯片模型

用于人肠芯片模型的人脐静脉内皮细胞（HUVEC）的收获和接种

HUVEC 和 C2BBe1 培养的生物芯片的微流控灌注，用于分析对微生物定植的免疫反应

Adrian Feile*^1,2,3, Valentin D. Wegner*¹, Martin Raasch⁴, Alexander S. Mosig^1,2,3,5

¹Institute of Biochemistry II,Jena University Hospital, ²Cluster of Excellence Balance of the Microverse,Friedrich Schiller University, ³Jena School of Microbial Communication,Friedrich Schiller University, ⁴Dynamic42 GmbH, ⁵Jena Center for Sepsis Control and Care,Jena University Hospital

Özet

我们的详细方案概述了高级肠芯片模型的创建和使用，该模型模拟具有 3D 结构和各种细胞类型的人类肠粘膜，能够深入分析响应微生物定植的免疫反应和细胞功能。

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