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Lumbar Puncture Delivery of AAV9 in Juvenile Rats for CNS Gene Therapy

Lumbar Puncture Delivery of AAV9 in Juvenile Rats for CNS Gene Therapy

March 29, 2024

Author Spotlight: Assessing Intrathecal Gene Therapy Efficacy in Juvenile Rats

01:24 min
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343 Views

Preparing Reagents to Deliver an Adeno-Associated Serotype 9 Vector

00:39 min
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37 Views

Delivering Gene Therapy Vectors via Lumbar Puncture in the Juvenile Rat

02:41 min
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79 Views
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1Department of Neurosurgery, School of Medicine,Emory University, 2Department of Human Genetics, School of Medicine,Emory University

Özet

A surgical procedure is described to perform injections into the lumbar cistern of the juvenile rat. This approach has been used for the intrathecal delivery of gene therapy vectors, but it is anticipated that this approach can be used for a variety of therapeutics, including cells and drugs.

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