脑成像的情感记忆的促进作用调查
Summary
我们提出了一个协议，它使用功能磁共振成像研究的情感记忆增强作用的神经关联。此协议允许专门与内存相关的处理，相反更一般的知觉加工的大脑活动的鉴定，可人口健康和临床使用。
Abstract
情感活动，往往能够更好地记住 1,2比非情感事件。认知和情感的神经科学家的目标之一是要了解底层的这种情感对记忆的促进作用的神经机制。一个已被证明在情感的记忆增强作用的调查，特别是有影响力的方法是所谓的后续内存范式（SMP）。该方法最初用于研究非情感的回忆3的神经关联，而最近我们和其他人也适用于它成功地情绪记忆的研究（4 5-7审查） 。在这里，我们描述了一个协议，允许调查的情感与事件相关功能磁共振成像（fMRI）结合使用的SMP的记忆增强作用的神经关联。在SMP的一个重要特点是，它使大脑活动的分离，专门从更普遍的感知与相关活动的内存的。此外，在调查的情绪刺激的影响的背景下，SMP允许的大脑区域的活动是容易受到情绪调节一般/知觉和记忆的具体处理的识别。该协议可用于8-15正常人，以及在临床患者，其中有情绪知觉和偏见的记忆情感的事件，如那些患有抑郁症和创伤后应激障碍（PTSD，神经关联的改变）16，17。
Protocol
1。实验设计，方法问题，及刺激在SMP包括两个任务，一个编码任务和检索任务，并记录大脑活动的过程中可能出现的编码任务，或在编码和检索任务（见图1）为说明的SMP设计图。 图1：SMP设计总图。在编码过程中，其活动的大脑区域比随后被遗忘的项目为后来想起（R> F）的编码成功（ES）?…
Discussion
这个实验的协议允许的情感记忆增强作用的神经关联的调查，特别是分离的记忆有关的脑活动，是容易受到情绪容易在一般/感性处理情感调制的大脑区域的活动，以调制的。这种设计已经在推进我们的情绪的影响，对内存的基本的神经机制理解，并给予它的多功能性这是预计，SMP将保持在决定如何事件是经历时各方面会后会影响一个人的至关重要回忆，重新体验，事件和相关的情感记忆的能力。…
Disclosures
The authors have nothing to disclose.
Acknowledgements
金融衍生工具，支持从全国联盟为精神分裂症和抑郁症的研究，并从加拿大精神病学研究基金会的俄共奖的青年研究者奖。
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Cite This Article
Shafer, A., Iordan, A., Cabeza, R., Dolcos, F. Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion. J. Vis. Exp. (51), e2433, doi:10.3791/2433 (2011).