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A 3D Blood-Brain Barrier Model Derived from Human Pluripotent Stem-Cells

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神経疾患のモデル化と治療標的化のための血液脳関門の in vitro 再構築

JoVE Journal
Neurociência

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JoVE Journal Neurociência

Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease

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神経疾患のモデル化と治療標的化のための血液脳関門の in vitro 再構築

A 3D Blood-Brain Barrier Model Derived from Human Pluripotent Stem-Cells

DOI:

10.3791/65921-v

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02:09 min

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October 20, 2023

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Camille Goldman*^1,2,3,4,5, Natalie Suhy*^1,2,3,4,5, Jessica E. Schwarz^2,3,4,5, Emily Ruth Sartori^2,3,4,5, Rikki B. Rooklin^2,3,4,5, Braxton R. Schuldt^2,3,4,5, Louise A. Mesentier-Louro^2,3,4,5, Joel W. Blanchard^2,3,4,5

¹Icahn School of Medicine at Mount Sinai, ²Black Family Stem Cell Institute at Mount Sinai, ³Ronald M. Loeb Center for Alzheimer’s Disease at Mount Sinai, ⁴Friedman Brain Institute at Mount Sinai, ⁵Nash Family Department of Neuroscience at Mount Sinai

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Keywords: Blood-brain Barrier In Vitro Model Alzheimer’s Disease Neurodegeneration Cerebrovascular Pathology APOE4 Amyloid Induced Pluripotent Stem Cells Personalized Therapy Drug Screening 3D Model BBB Function Cerebral Amyloid Angiopathy

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