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Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
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Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
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January 20, 2023
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Here, it is demonstrated how an awake closed-head injury model can be used for examining the effects of repeated mild traumatic brain injury (r-mTBI) on synaptic plasticity in the hippocampus. The model replicates important features of r-mTBI in patients and is used in conjunction with in vitro electrophysiology.
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Christie, B. R., Gross, A., Willoughby, A., Grafe, E., Brand, J., Bosdachin, E., Reid, H. M. O., Acosta, C., Eyolfson, E. Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury. J. Vis. Exp. (191), e64592, doi:10.3791/64592 (2023).
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