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1-（2-[^18F]氟乙基）-L-色氨酸的放射性合成，采用一锅两步实验方案

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Química

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JoVE Journal Química

Radiosynthesis of 1-(2-[¹⁸F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol

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1-（2-[^18F]氟乙基）-L-色氨酸的放射性合成，采用一锅两步实验方案

DOI:

10.3791/63025-v

•

08:33 min

•

September 21, 2021

•

Xuyi Yue², Rahul M. Nikam², Heidi H. Kecskemethy², Vinay V. R. Kandula, Stephen J. Falchek, Lauren W. Averill², Sigrid A. Langhans⁴

¹Diagnostic & Research PET/MRI Center,Nemours/Alfred I. duPont Hospital for Children, ²Department of Radiology,Nemours/Alfred I. duPont Hospital for Children, ³Department of Neurology,Nemours/Alfred I. duPont Hospital for Children, ⁴Department of Biomedical Research,Nemours/Alfred I. duPont Hospital for Children

Capítulos

00:04Introduction
00:50Radiosynthesis of L-[¹⁸F]FETrp
07:05Results: Quality Control and Stability Test Results of L-[¹⁸F]FETrp
08:02Conclusion

Summary

Tadução automática

在这里，我们描述了1-（2-[^18F]氟乙基）-L-色氨酸的放射合成，这是一种用于研究色氨酸代谢的正电子发射断层扫描成像剂，在放射化学合成系统中使用一锅两步策略，具有良好的放射化学产率，高对映体过量和高可靠性。

Tags

Radiosynthesis 1-(2-[18F]Fluoroethyl)-L-Tryptophan One-pot Two-step Protocol F18 Radiolabeled Tryptophan Tracer Tryptophan Metabolism Radioisotope QMA Light Cartridge K222 Potassium Carbonate Reactor Argon Evaporation Compressed Carbon Dioxide

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