This protocol noninvasively induces hyperglycemia in zebrafish for up to 8 weeks. Using this protocol, an in-depth study of the adverse effects of hyperglycemia can be made.
McCarthy, E., Rowe, C. J., Crowley-Perry, M., Connaughton, V. P. Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish. J. Vis. Exp. (171), e61935, doi:10.3791/61935 (2021).